Nanomaterials, biosensors and medical diagnostics (NBD)

Our research is focused on the development of sensors and biosensors based on electrochemical, optical and mass detection techniques.

Main research topics include:

  • Synthesis, modification and stabilization of nanostructures (quantum dots, metallic nanoparticles, graphene) for bioanalytical studies
  • Construction and characterization of receptor layers formed of native DNA, aptamers and DNA analogues for detection of nucleic acid strands, metal cations and protein biomarkers
  • Construction of immunosensors
  • Development of recognition layers for biosensing based on immobilized enzymes
  • Synthesis and application of novel nanoparticles and metallocomplexes as proteins’ labels with catalytic activity
  • Development of (bio)sensors with polymeric ion-selective membranes (new ionophores for hydrophilic anions, novel polymeric matrices compatible with potentiometric or optical transducers)
  • Development of intermediate layers (hydrogels, conducting polymers, self-assembled monolayers) for miniaturized ion-selective electrodes
  • Development of electroactive self-assembling monolayers
  • Design and fabrication of novel silicon-based transducers for potentiometric and voltammetric measurements
  • Application of FIA systems for bioanalyte determination
  • Electrochemical workstations (660A, 660D, 1040A series and 440C (combined with quartz microbalance)) for electrochemical measurements – e.g. voltammetry, amperometry, coulometry, impedance etc., CH Instruments
  • EMF16 Interface (4 stations) for potentiometry measurements, Lawson Labs Inc.
  • Lambda 25 UV-VIS spectrophotometer, Perkin Elmer
  • Surface plasmon resonance spectroscopy with imaging, SPRi Lab, Horiba
  • Sunrise absorbance microplate reader, Tecan
  • Flow – injection systems

Currently executed projects:

Past projects:

  • M. Jarczewska, Studies on the receptor layers of affinity-based biosensors for early detection of cancer biomarkers,  01-08-2018, 31-05-2019 (dean’s grant)
  • M. Pietrzak, Nanoparticles of noble metals, which mimick the activity of peroxidase, catalase and superoxide dismutase, 2017/01/X/ST5/00034, 10-08-2017, 09-08-2018 (Miniatura 1, NCN)
  • M. Drozd, Studies on application of dithiocarbamates chemisorption as a strategy of (bio)receptor layers immobilization on gold transducers, 2014/15/N/ST5/02015, 22-09-2015, 21-09-2017 (Preludium 8, NCN)
  • M. Jarczewska, Studies on receptor layers formed by DNA and RNA aptamers in respect of their potential application in biosensors for detection of cardiac protein biomarkers, 2014/15/N/ST4/02980, 03-09-2015, 02-07-2017 (Preludium 8, NCN)
  • Ł. Górski, Electrochemical sensors with DNA receptor layer for heavy metal ions determination, 2013/11/B/ST4/00766, 01-06-2014, 31-12-2016 (Opus 6, NCN)
  • R. Ziółkowski, Investigations on the application of graphene as a novel basis of electrochemical biosensors containing nucleic acids in the receptor layer, IP2012 064972, 18-06-2013, 31-12-2014 (Iuventus Plus 2012, MNiSW)
  • M. Mroczkiewicz, Studies on the application of Acetate – Selective Electrode as detectors in flow – through system for bioanalytes determination, 2011/01/N/ST4/03352, 01-12-2011 , 30-09-2013 (Preludium 1, NCN)
  • R. Ziółkowski, Studies on biosensor’s receptor layers composed of oligonucleotides, 2011/01/N/ST4/03330, 01-12-2011 , 30-09-2013 (Preludium 1, NCN)
  • E. Malinowska, Design and characterization of the receptor layers of sensors and biosensors, N N204 125237, 30-09-2009, 30-06-2012 (NCN/KBN)

Publications

2019

2018

2017

2016

2015

2014

2013

2012

2011

2010

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2000

Applied:

  • Ziółkowski R.,  Jastrzębska E., Spólnik I., Dybko A., Malinowska E., Brzózka Z., Przepływowy mikrosystem do przeprowadzenia łańcuchowej reakcji polimerazy (PCR), P.428242, 2018