Microtechnology and organ-on-a-chip systems research group
Research Description
The Microtechnology and Organ-on-a-Chip Systems Research Group is operating in the Department of Medical Biotechnology of the Faculty of Chemistry at the Warsaw University of Technology. Research concerns the development of microfluidic systems (Organ-on-a-Chip systems) for cell engineering with clinical and biomedical applications. We develop Organ-on-a-Chip systems with 3D models (based on spheroids, organoids, hydrogels, scaffolds) of different organs, i.e., the liver, heart, neurovascular unit, breast, ovary, and intestine. The research also concerns the study of molecular mechanisms and metabolic pathways in tumor and stem cell-based models. We are also working under the new technologies and alternative (bio)materials useful in microtechnology. The Organ-on-a-Chip systems developed in our team allow to obtain new data on cell biology and they could be served as platforms in personalized medicine.
Equipment
- 3D printers
- Cell incubators
- Real-Time PCR system, Qubit fluorometer
- Plasma generator
- Centrifuge
- Laminar chambers
- Fluoroscence and optical microscopes
- Multi-well plate reader
Collaboration
- University of Gdańsk, Faculty of Chemistry
- Jagiellonian University
- Nencki Institute of Experimental Biology
- International Institute of Molecular and Cell Biology in Warsaw
- Universita Ca Foscari Venezia
- Warsaw University of Life Sciences
- Warsaw University of Technology, Faculty of Chemical and Process Engineering, Faculty of Physics, Centre for Advanced Materials and Technology
Offered research services
- Microprototyping
- Design and fabrication of microfluidic systems
- Comprehensive 3D cell cultures with vascularization
- Molecular and Cellular Analysis
Cytoxicity assessment of pharmaceuticals and chemicals
Patents
- Flow microsystem integrated with nanofiber mats for cell culture and cell regeneration studies, Patent: PL 240974, 2022
- Flow microsystem for performing polymerase chain reaction (PCR), Patent: PL 242508, 2022
- Flow microsystem for creation, culture and fluorescence imaging of three-dimensional aggregates of pancreatic islet cells, Patent: PL 239354
- Flow microsystem for three-dimensional cell culture, Patent: PL 239601
- Multi-Organ-on-Chip microsystem for multi-organ culture and its application, Pat. App. P.4468130


