BioPep MINDS - Bioactive Peptides Metals & Integrated Neurodegeneration Studies

Our research group focuses on uncovering the molecular mechanisms by which metal complexes of bioactive peptides contribute to the onset and progression of neurodegenerative diseases, with special attention to the role of oxidative stress. Our aim is to translate these findings into novel diagnostic and therapeutic approaches for these currently incurable diseases, including Alzheimer’s disease. 

We also explore the properties of metal-peptide complexes for their potential use in antimicrobial and anticancer treatments, as well as in the cosmetic industry. 

By leveraging our in-depth knowledge of peptides and our multidisciplinary strengths in bioinorganic, biophysical, and analytical chemistry —supported by collaborations in machine learning, cellular studies, and organic synthesis — we aspire to discover new application areas for bioactive peptides.

 

Ph.D. Students:

  • Microplate reader FLUOstar Omega BMG LABTECH
  • Cary 3500 Compact and Cary 60 UV-Vis spectrophotometers
  • Spectroelectrochemical Instrument SPELEC
  • Multi-channel potentiostats CH Instrument
  • E-Gel Power Snap Electrophoresis System
  • Equipment for optical characterization of various samples (spectrophotometers, microplate readers)
  • Eppendorf ThermoMixer C.

 

  • Christelle Hureau, LCC-CNRS, Université de Toulouse, CNRS, Toulouse, France
  • Peter Faller, Institut de Chimie (UMR 7177), Université de Strasbourg, CNRS, 67000 Strasbourg, France
  • Wojciech Bal, Tomasz Frączyk, Institute of Biochemistry and Biophysics Polish Academy of Sciences
  • Wojciech Kamysz, Medical University of Gdańsk, Poland
  • Patrycja Baranowska, Centre for Advanced Materials and Technologies, Warsaw University of Technology, Poland
  • characterization of pro-oxidative properties of compounds;
  • characterization of electrochemical properties of metal-peptide complexes;
  • characterization of spectroscopic and spectroelectrochemical properties of compounds;
  • preliminary studies on nucleic acid cleavage by compounds;
  • designing of peptide sequences for a given application